Factor VIII gene variants and inhibitor risk in African American hemophilia A patients
Copyright policy )Factor VIII gene variants and inhibitor risk in African American hemophilia A patients
Key Points Immune responses to FVIII sequence variants encoded by ns-SNPs do not contribute appreciably to inhibitor development in African Americans. African American HA subjects with an intron-22 inversion had a 2- to 3-times-higher inhibitor incidence than whites with the same mutation.
- Bloodworks Northwest United States
- CHI Franciscan Health United States
- United States Department of Veterans Affairs United States
- Benaroya Research Institute United States
- Seattle Children's United States
Adult, CD4-Positive T-Lymphocytes, Male, Factor VIII, Adolescent, Molecular Sequence Data, Genetic Variation, Hemophilia A, Antibodies, Neutralizing, Peptide Fragments, Black or African American, Haplotypes, Child, Preschool, Humans, Mutant Proteins, Amino Acid Sequence, Child, Epitope Mapping, Autoantibodies, HLA-DRB1 Chains
Adult, CD4-Positive T-Lymphocytes, Male, Factor VIII, Adolescent, Molecular Sequence Data, Genetic Variation, Hemophilia A, Antibodies, Neutralizing, Peptide Fragments, Black or African American, Haplotypes, Child, Preschool, Humans, Mutant Proteins, Amino Acid Sequence, Child, Epitope Mapping, Autoantibodies, HLA-DRB1 Chains
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