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Genetically Encoded Activators of Small Molecules for Imaging and Drug Delivery

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 27 Feb 2020Embargo end date: 11 May 2020 Switzerland Publisher:WileyJournal:Angewandte Chemie International Edition, volume 59, pages 7,669-7,677 (issn: 1433-7851, eissn: 1521-3773,

Authors: Zacharias Thiel; Jade Nguyen; Pablo Rivera‐Fuentes;

doi: 10.1002/anie.201915521 , 10.1002/ange.201915521 , 10.3929/ethz-b-000404712

pmid: 31898373

pmc: PMC7318188

handle: 20.500.11850/404712

Genetically Encoded Activators of Small Molecules for Imaging and Drug Delivery

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Abstract

AbstractChemical biologists have developed many tools based on genetically encoded macromolecules and small, synthetic compounds. The two different approaches are extremely useful, but they have inherent limitations. In this Minireview, we highlight examples of strategies that combine both concepts to tackle challenging problems in chemical biology. We discuss applications in imaging, with a focus on super‐resolved techniques, and in probe and drug delivery. We propose future directions in this field, hoping to inspire chemical biologists to develop new combinations of synthetic and genetically encoded probes.

Country

Switzerland

Related Organizations

ETH Zurich
Switzerland
École Polytechnique Fédérale de Lausanne EPFL
Switzerland
Agency for Science, Technology and Research
Singapore
Institute of Chemical and Engineering Sciences
Singapore
Laboratory of Organic Chemistry
Switzerland

Keywords

Minireviews, Bioorthogonal labeling, Molecular Imaging, Small Molecule Libraries, Drug Delivery Systems, Biosensors, Drug delivery, Fluorescent probes, Bioorthogonal labeling; Biosensors; Drug delivery; Fluorescent probes; Genetically encoded tags, Animals, Humans, Genetically encoded tags, Genetic Engineering

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	8
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%