Expression of pituitary adenylate cyclase-activating polypeptide 1 and 2 receptor mRNA in gallbladder tissue of patients with gallstone or gallbladder polyps
Copyright policy )Expression of pituitary adenylate cyclase-activating polypeptide 1 and 2 receptor mRNA in gallbladder tissue of patients with gallstone or gallbladder polyps
To detect the expression of pituitary adenylate cyclase-activating polypeptide receptor 1 (VPCAP1-R)and VPCAP2-R mRNA in gallbladder tissues of patients with gallstone or gallbladder polyps.The expression of VPCAP1-R and VPCAP2-R mRNA in gallbladder tissues was detected in 25 patients with gallstone,8 patients with gallbladder polyps and 7 donors of liver transplantation by reverse transcription polymerase chain reaction (RT-PCR).The VPCAP2-R mRNA expression level in the control group (1.09+/-0.58) was lower than that in the gallbladder polyp group (1.64+/-0.56) and the gallstone group (1.55+/-0.45) (P<0.05) while the VPCAP1-R mRNA expression level in the control group (1.15+/-0.23) was not apparently different from that in the gallbladder polyp group (1.28+/-0.56) and the gallstone group (1.27+/-0.38).The abnormal expression of VPCAP2-R mRNA in gallbladder tissue may play a role in the formation of gallbladder stone and gallbladder polyps.
- China Medical University China (People's Republic of)
Adult, Male, Receptors, Vasoactive Intestinal Polypeptide, Type I, Reverse Transcriptase Polymerase Chain Reaction, Gallbladder, Gallbladder Diseases, Gallstones, Middle Aged, Polyps, Gene Expression Regulation, Humans, Female, RNA, Messenger, Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
Adult, Male, Receptors, Vasoactive Intestinal Polypeptide, Type I, Reverse Transcriptase Polymerase Chain Reaction, Gallbladder, Gallbladder Diseases, Gallstones, Middle Aged, Polyps, Gene Expression Regulation, Humans, Female, RNA, Messenger, Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
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