Circulating CD8+CD56−perforin+ T cells are increased in multiple sclerosis patients
Copyright policy )Circulating CD8+CD56−perforin+ T cells are increased in multiple sclerosis patients
Relapsing-remitting multiple sclerosis (RRMS), secondary progressive (SP)MS and primary progressive (PP)MS patients showed higher percentages of circulating CD8+CD56-perforin+ T cells than controls whereas only relapsing RRMS and PPMS patients showed higher perforin expression in CD8+CD56- T cells than controls. MS patients with EDSS ≥3 showed higher percentage of CD8+CD56-perforin+ T cells than patients with EDSS <3 and controls whereas patients with EDSS <3 showed higher percentage of this T cell subpopulation than controls. Our data show that MS is characterized by a dysregulation of CD8+CD56-perforin+ T cells that may play a role in the development of disability.
- UCL Queen Square Institute of Neurology United Kingdom
- Catholic University of the Sacred Heart Italy
- University of Siena Italy
- Pontifícia Universidade Católica de São Paulo Brazil
- University College London United Kingdom
Adult, Male, Multiple sclerosis, Perforin, CD8 T cells, Disability progression, Perforin, 610, Epitopes, T-Lymphocyte, CD8 T cells, CD8-Positive T-Lymphocytes, Middle Aged, Multiple Sclerosis, Chronic Progressive, multiple sclerosis, CD56 Antigen, Immunophenotyping, Multiple sclerosis, Multiple Sclerosis, Relapsing-Remitting, T-Lymphocyte Subsets, Disease Progression, Humans, Female, Lymphocyte Count, Disability progression
Adult, Male, Multiple sclerosis, Perforin, CD8 T cells, Disability progression, Perforin, 610, Epitopes, T-Lymphocyte, CD8 T cells, CD8-Positive T-Lymphocytes, Middle Aged, Multiple Sclerosis, Chronic Progressive, multiple sclerosis, CD56 Antigen, Immunophenotyping, Multiple sclerosis, Multiple Sclerosis, Relapsing-Remitting, T-Lymphocyte Subsets, Disease Progression, Humans, Female, Lymphocyte Count, Disability progression
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