Amplification and overexpression of KIT, PDGFRA, and VEGFR2 in medulloblastomas and primitive neuroectodermal tumors
Copyright policy )Amplification and overexpression of KIT, PDGFRA, and VEGFR2 in medulloblastomas and primitive neuroectodermal tumors
Medulloblastomas (MB) and primitive neuroectodermal tumors (PNET) are the most common malignant brain tumors in children. These two tumor types are histologically similar, but have different genetic backgrounds and clinical outcomes. Other brain tumors, such as gliomas, frequently have coamplification and overexpression of receptor tyrosine kinases KIT, platelet-derived growth factor receptor alpha (PDGFRA), and vascular endothelial growth factor receptor 2 (VEGFR2). We investigated protein expression and gene copy numbers of KIT, PDGFRA, and VEGFR2 in 41 MB and 11 PNET samples by immunohistochemistry (IHC) and chromogenic in situ hybridization (CISH). KIT and PDGFRA expression was detected in both MBs and PNETs, whereas VEGFR2 expression was weak in these tumors. KIT, PDGFRA, and VEGFR2 amplifications were all present in 4% of MBs/PNETs, and KIT amplification was associated with concurrent PDGFRA and VEGFR2 amplifications (P
- Tampere University Hospital Finland
- Helsinki University Hospital Finland
- University of Turku Finland
- University of Helsinki Finland
Male, Stem Cell Factor, Receptor, Platelet-Derived Growth Factor alpha, Brain Neoplasms, Gene Dosage, Kaplan-Meier Estimate, Immunohistochemistry, Vascular Endothelial Growth Factor Receptor-2, Humans, Neuroectodermal Tumors, Primitive, Cerebellar Neoplasms, In Situ Hybridization, Medulloblastoma
Male, Stem Cell Factor, Receptor, Platelet-Derived Growth Factor alpha, Brain Neoplasms, Gene Dosage, Kaplan-Meier Estimate, Immunohistochemistry, Vascular Endothelial Growth Factor Receptor-2, Humans, Neuroectodermal Tumors, Primitive, Cerebellar Neoplasms, In Situ Hybridization, Medulloblastoma
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