During the past year Kelser1 has prepared a chloroform-treated tissue-vaccine for rinderpest which is highly efficacious in protecting cattle and carabaos against this disease. Kakisaki, Nakanishi and Nakamura2 in Japan have also prepared a tissue-vaccine for this disease by treating the infected tissues with toluol, ether, etc. The vaccine prepared by the Japanese workers is difficult to administer because of its consistency and is also absorbed very slowly. In the Philippines the Kelser vaccine has now been adopted as the standard method of protection against rinderpest and its efficiency approaches 100%. In more recent work Kelser3 has prepared a chloroform-treated tissue-vaccine for rabies.Briefly the chloroform-treated tissue vaccine for rinderpest as prepared by Kelser consists of finely ground tissues (lymph glands, tonsils, spleen, liver) from animals killed in the acute stages of rinderpest. This tissue is diluted with equal parts of physiological saline and for each 100 cc. of tissue emulsion 0....