Four new HLA class I alleles in Cauacasoids*
Copyright policy )Four new HLA class I alleles in Cauacasoids*
Abstract: Four new HLA classical class I alleles in the three loci are described in Caucasian individuals. A*3012 was first suspected by an abnormal serologic pattern that would be explained by the single amino acid substitution at the A30‐specific Ser17. B*270505 differs from B*270502 in a silent substitution at an up to now constant position in the B locus. B*3541 encodes for a new Cys at position 118 that has not been encountered in neither human nor primate alleles. Cw*0716 seems to be originated by a large‐scale interallelic recombination event between Cw*0701/*0706/*0718 and Cw*020202, giving rise to a new antigen‐binding cleft conformation.
Recombination, Genetic, Heterozygote, Polymorphism, Genetic, Base Sequence, HLA-A Antigens, Histocompatibility Testing, Histocompatibility Antigens Class I, Molecular Sequence Data, Genes, MHC Class I, HLA-C Antigens, Introns, White People, HLA-B Antigens, Mutation, Humans, Amino Acid Sequence, Cysteine, Alleles
Recombination, Genetic, Heterozygote, Polymorphism, Genetic, Base Sequence, HLA-A Antigens, Histocompatibility Testing, Histocompatibility Antigens Class I, Molecular Sequence Data, Genes, MHC Class I, HLA-C Antigens, Introns, White People, HLA-B Antigens, Mutation, Humans, Amino Acid Sequence, Cysteine, Alleles
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