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The Swi/Snf Chromatin Remodeling Complex Is Required for Ribosomal DNA and Telomeric Silencing in Saccharomyces cerevisiae

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2004Publisher:Informa UK LimitedJournal:Molecular and Cellular Biology, volume 24, pages 8,227-8,235 (eissn: 1098-5549,

Authors: Fred Winston; Vardit Dror; Vardit Dror;

doi: 10.1128/mcb.24.18.8227-8235.2004

pmid: 15340082

pmc: PMC515061

The Swi/Snf Chromatin Remodeling Complex Is Required for Ribosomal DNA and Telomeric Silencing in Saccharomyces cerevisiae

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Abstract

The Swi/Snf chromatin remodeling complex has been previously demonstrated to be required for transcriptional activation and repression of a subset of genes in Saccharomyces cerevisiae. In this work we demonstrate that Swi/Snf is also required for repression of RNA polymerase II-dependent transcription in the ribosomal DNA (rDNA) locus (rDNA silencing). This repression appears to be independent of both Sir2 and Set1, two factors known to be required for rDNA silencing. In contrast to many other rDNA silencing mutants that have elevated levels of rDNA recombination, snf2Delta mutants have a significantly decreased level of rDNA recombination. Additional studies have demonstrated that Swi/Snf is also required for silencing of genes near telomeres while having no detectable effect on silencing of HML or HMR.

Related Organizations

Harvard University
United States
Tel Aviv University
Israel

Keywords

Adenosine Triphosphatases, Recombination, Genetic, Saccharomyces cerevisiae Proteins, Base Sequence, Genes, Fungal, Nuclear Proteins, Histone-Lysine N-Methyltransferase, Saccharomyces cerevisiae, Telomere, Chromatin Assembly and Disassembly, DNA, Ribosomal, Histone Deacetylases, DNA-Binding Proteins, Sirtuin 2, Mutagenesis, Sirtuins, Gene Silencing, DNA, Fungal, Promoter Regions, Genetic, Silent Information Regulator Proteins, Saccharomyces cerevisiae

3 Research products, page 1 of 1

NAD-dependent histone deacetylase SIR2
2017IsRelatedTo
Histone-lysine N-methyltransferase, H3 lysine-4 specific
2017IsRelatedTo
Transcription regulatory protein SNF2
2017IsRelatedTo

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