Powered by OpenAIRE graph
Found an issue? Give us feedback
downloadFull-Text
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Archivio Istituziona...arrow_drop_down
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila
Article . 2020
License: CC 0
Full-Text: https://ricerca.univaq.it/bitstream/11697/157520/1/nat_med_2020.pdf
Data sources: Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
Nature Medicine
Article
License: Springer TDM
Full-Text: http://www.nature.com/articles/s41591-020-0868-6.pdf
Data sources: Sygma
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
Nature Medicine
Article . 2020
License: Springer TDM
Full-Text: http://www.nature.com/articles/s41591-020-0868-6.pdf
Data sources: WHO Global literature on coronavirus disease
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
Expeditio - Repositorio Institucional Universidad de Bogotá Jorge Tadeo Lozano (UTADEO)
Article . 2020
Full-Text: http://hdl.handle.net/20.500.12010/10814
Data sources: Bielefeld Academic Search Engine (BASE)
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
Nature Medicine
Article
Data sources: UnpayWall
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
Apollo
Article . 2020
Data sources: Datacite
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
arXiv.org e-Print Archive
Preprint . 2020
Data sources: arXiv.org e-Print Archive
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
Nature Medicine
Article . 2020
License: taverne
Data sources: University of Groningen Research Portal
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
Apollo
Article . 2020
Data sources: Apollo
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
UCL Discovery
Article . 2020
Data sources: UCL Discovery
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
Research.fi
Article . 2021 . Peer-reviewed
License: CC BY
Data sources: Research.fi
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Nature Medicine
Article . 2020 . Peer-reviewed
License: Springer TDM
Data sources: Crossref
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
HAL Sorbonne Université
Article . 2020
Data sources: HAL Sorbonne Université
https://dx.doi.org/10.48550/ar...
Article . 2020
License: CC BY NC SA
Data sources: Datacite
https://pubmed.ncbi.nlm.nih.go...
Article
Data sources: Europe PubMed Central
https://pubmed.ncbi.nlm.nih.go...
Article
Data sources: Europe PubMed Central
https://arxiv.org/abs/2003.061...
Other literature type
Data sources: Microsoft Academic Graph
Nature Medicine
Article
Data sources: Microsoft Academic Graph
Nature Medicine
Article . 2020 . Peer-reviewed
Data sources: European Union Open Data Portal
MTAK: REAL (Library and Information Centre of the Hungarian Academy of Sciences
Article . 2020
Data sources: Bielefeld Academic Search Engine (BASE)
The University of Queensland: UQ eSpace
Article . 2020
Data sources: Bielefeld Academic Search Engine (BASE)
Newcastle University Library ePrints Service
Article . 2020
Data sources: Bielefeld Academic Search Engine (BASE)
 View all 16 versions
Claim

This Research product is the result of merged Research products in OpenAIRE.

You have already added 0 works in your ORCID record related to the merged Research product.

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

descriptionPublicationkeyboard_double_arrow_right Article , Preprint , Other literature type 23 Apr 2020Embargo end date: 16 Apr 2020 English Publisher:Springer Science and Business Media LLCJournal:Nature Medicine, volume 26, pages 681-687 (issn: 1078-8956, eissn: 1546-170X, Copyright policy )Funded by:NIH | An integrated multiplexed..., NIH | Genetic Control of Airway..., NIH | Genomic Analysis of Tissu... +22 projects
Authors: Sungnak W.; Huang N.; Becavin C.; Berg M.; Queen R.; Litvinukova M.; Talavera-Lopez C.; +73 Authors

doi: 10.1038/s41591-020-0868-6 , 10.17863/cam.51512 , 10.48550/arxiv.2003.06122

pmid: 32327758 , 32550242

pmc: PMC8637938 , PMC7280877

arXiv: http://arxiv.org/abs/2003.06122

handle: 11370/d8a5a441-2bbb-4e32-b266-c0c2707f3534 , 11697/157520 , 20.500.12010/10814

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

Abstract

We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.

Related Organizations
View all View all
Keywords

1300 Biochemistry, Immunology, PROTEIN, Genetics and Molecular Biology, CORONAVIRUS, General Biochemistry, Genetics and Molecular Biology, Nasal epithelial cells, HCA Lung Biological Network, Síndrome respiratorio agudo grave, FUNCTIONAL RECEPTOR, Virology, Cell Behavior (q-bio.CB), Transcriptomics, QH3011 Biochemistry / biokémia, SARS-CoV-2, COVID-19, General Medicine, Coronavirus, [SDV] Life Sciences [q-bio], WUHAN, FOS: Biological sciences, General Biochemistry, Células epiteliales nasales, Quantitative Biology - Cell Behavior

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 2K
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 0.01%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 0.01%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 0.01%
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2K
Top 0.01%
Top 0.01%
Top 0.01%
Green
hybrid
Related to Research communities
Corona Virus Disease
Knowmad Institut
Netherlands Research Portal
UArctic