Genome-Wide Association Study Identifies HLA-DP as a Susceptibility Gene for Pediatric Asthma in Asian Populations
Copyright policy )Genome-Wide Association Study Identifies HLA-DP as a Susceptibility Gene for Pediatric Asthma in Asian Populations
Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted a genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients and 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10(-8)) in GWAS were further genotyped in an independent Japanese samples (818 cases and 1,032 controls) and in Korean samples (835 cases and 421 controls). SNP rs987870, located between HLA-DPA1 and HLA-DPB1, was consistently associated with pediatric asthma in 3 independent populations (P(combined) = 2.3×10(-10), odds ratio [OR] = 1.40). HLA-DP allele analysis showed that DPA1*0201 and DPB1*0901, which were in strong linkage disequilibrium, were strongly associated with pediatric asthma (DPA1*0201: P = 5.5×10(-10), OR = 1.52, and DPB1*0901: P = 2.0×10(-7), OR = 1.49). Our findings show that genetic variants in the HLA-DP locus are associated with the risk of pediatric asthma in Asian populations.
- Dokkyo Medical University Japan
- Asan Medical Center Korea (Republic of)
- National Cancer Research Institute United Kingdom
- Chiba University Japan
- National Center of Neurology and Psychiatry Japan
Male, HLA-DP Antigens, Adolescent, QH426-470, HLA-DP alpha-Chains, Polymorphism, Single Nucleotide, Asthma, Asian People, Gene Frequency, Haplotypes, Case-Control Studies, Child, Preschool, Genetics, Humans, Female, Genetic Predisposition to Disease, Child, Alleles, HLA-DP beta-Chains, Research Article, Genome-Wide Association Study
Male, HLA-DP Antigens, Adolescent, QH426-470, HLA-DP alpha-Chains, Polymorphism, Single Nucleotide, Asthma, Asian People, Gene Frequency, Haplotypes, Case-Control Studies, Child, Preschool, Genetics, Humans, Female, Genetic Predisposition to Disease, Child, Alleles, HLA-DP beta-Chains, Research Article, Genome-Wide Association Study
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