Distribution of killer cell immunoglobulin-like receptor genes in the mestizo population from Venezuela
Copyright policy )Distribution of killer cell immunoglobulin-like receptor genes in the mestizo population from Venezuela
This study represents the first report on the distribution of KIR genes in 205 unrelated healthy mestizo Venezuelan individuals. Genotyping analysis showed that all KIR genes are present in this population. Frequency of inhibitory killer cell immunoglobulin-like receptors (KIRs) exceeded 0.69, except for KIR2DL2 (0.29) and 2DL5 (0.37). Activating KIRs showed low frequencies (0.11-0.29), except for KIR2DS4 (0.68). Forty-five different KIR genotypes were identified, with a predominance of three genotypes found in 50.7% of the population of which 25.9% were individuals homozygous for haplotype A. The frequencies of KIR genes reflect the ethnic admixture existing in the mestizo Venezuelan population.
- Science Applications International Corporation (United States) United States
- Massachusetts Institute of Technology United States
- Universidad Central de Venezuela, Facultad de Medicina. Venezuela
- Harvard University United States
- Instituto Venezolano de Investigaciones Científicas Venezuela
Gene Frequency, Receptors, KIR, Population, Humans, Venezuela, Phylogeny
Gene Frequency, Receptors, KIR, Population, Humans, Venezuela, Phylogeny
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