Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells
Copyright policy )Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells
Radiotherapy is effective for treating various types of tumors. However, some cancer cells survive after irradiation and repopulate tumors with highly malignant phenotypes that correlate with poor prognosis. It is not known how cancer cells survive and generate malignant tumors after irradiation. Here, we show that activating transcription factor 5 (ATF5) promotes radioresistance and malignancy in cancer cells after irradiation. In the G1-S phase of the cell cycle, cancer cells express high levels of ATF5, which promotes cell cycle progression and thereby increases radioresistance. Furthermore, ATF5 increases malignant phenotypes, such as cell growth and invasiveness, in cancer cells in vitro and in vivo. We have identified a new mechanism for the regeneration of highly malignant tumors after irradiation and shown that ATF5 plays a key role in the process.
- Hokkeido University Japan
- Hokkaido Bunkyo University Japan
- Hokkaido University Japan
Male, Lung Neoplasms, 490, Blotting, Western, Mice, Nude, Apoptosis, Activating transcription factor 5, Adenocarcinoma, Immunoenzyme Techniques, Mice, Carcinoma, Non-Small-Cell Lung, cell growth, Animals, Humans, RNA, Messenger, Cell Proliferation, Neoplasm Staging, Mice, Inbred BALB C, Cell Cycle, cell invasion, Prognosis, Activating Transcription Factors, radioresistance, Gene Expression Regulation, Neoplastic, cancer cells, Carcinoma, Squamous Cell
Male, Lung Neoplasms, 490, Blotting, Western, Mice, Nude, Apoptosis, Activating transcription factor 5, Adenocarcinoma, Immunoenzyme Techniques, Mice, Carcinoma, Non-Small-Cell Lung, cell growth, Animals, Humans, RNA, Messenger, Cell Proliferation, Neoplasm Staging, Mice, Inbred BALB C, Cell Cycle, cell invasion, Prognosis, Activating Transcription Factors, radioresistance, Gene Expression Regulation, Neoplastic, cancer cells, Carcinoma, Squamous Cell
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