Aryl Hydrocarbon Hydroxylase Induction by Polycyclic Hydrocarbons: Simple Autosomal Dominant Trait in the Mouse
Copyright policy )Aryl Hydrocarbon Hydroxylase Induction by Polycyclic Hydrocarbons: Simple Autosomal Dominant Trait in the Mouse
MANY mixed function1 oxygenases are membrane-bound multicomponent enzyme systems which require NADPH and molecular oxygen for the oxidative metabolism of polycyclic hydrocarbons, drugs and insecticides, as well as numerous lipophilic endogenous substrates2–4. Any day to day fluctuations in these enzyme activities may therefore influence the intensity and duration of drug action and also the rate of metabolism of chemical carcinogens, insecticides and many normal body substrates.
- National Institutes of Health United States
- National Institute of Health Pakistan
- Jackson Laboratory United States
Male, DBA/2 (212), 610, Gestational Age, Mice, Inbred Strains, Biochemistry, Mixed Function Oxygenases, Genes: Ahh - Arylhydroxylase (all)-Ah, Mice, Fetus, Metabolism:, Tissue Culture:, Animals, Maternal-Fetal Exchange, Molecular Biology, Crosses, Genetic, Genes, Dominant, Unknown:, Carcinogenesis:, 500, Genetic Variation, Strains: C57BL/6, Hydrocarbons, Organs:, Life-History Effects:, Animals, Newborn, Enzyme Induction, Embryology:, Microsomes, Liver, Hybridization, Genetic, Female, Hereditary Factors:, Injections, Intraperitoneal, Methylcholanthrene
Male, DBA/2 (212), 610, Gestational Age, Mice, Inbred Strains, Biochemistry, Mixed Function Oxygenases, Genes: Ahh - Arylhydroxylase (all)-Ah, Mice, Fetus, Metabolism:, Tissue Culture:, Animals, Maternal-Fetal Exchange, Molecular Biology, Crosses, Genetic, Genes, Dominant, Unknown:, Carcinogenesis:, 500, Genetic Variation, Strains: C57BL/6, Hydrocarbons, Organs:, Life-History Effects:, Animals, Newborn, Enzyme Induction, Embryology:, Microsomes, Liver, Hybridization, Genetic, Female, Hereditary Factors:, Injections, Intraperitoneal, Methylcholanthrene
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