TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains?
Copyright policy )TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains?
A family of membrane-associated proteins related to yeast Lag1p and mammalian TRAM has been identified. The family includes the protein product of CLN8, a gene mutated in progressive epilepsy with mental retardation. Mouse CLN8 is also mutated in the mnd/mnd mouse, a model for neuronal ceroid lipofuscinoses. The identification of these homologues has potential implications for our understanding of ceramide synthesis, lipid regulation and protein translocation in the endoplasmic reticulum.
- University of Oxford United Kingdom
Membrane Glycoproteins, Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid, Molecular Sequence Data, Membrane Proteins, Membrane Transport Proteins, Lipid Metabolism, Protein Structure, Tertiary, Fungal Proteins, Mice, Mutation, Animals, Humans, Amino Acid Sequence
Membrane Glycoproteins, Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid, Molecular Sequence Data, Membrane Proteins, Membrane Transport Proteins, Lipid Metabolism, Protein Structure, Tertiary, Fungal Proteins, Mice, Mutation, Animals, Humans, Amino Acid Sequence
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