Aberrant Expression ofHOXA9,DEK,CBLandCSF1Rin Acute Myeloid Leukemia
Copyright policy )Aberrant Expression ofHOXA9,DEK,CBLandCSF1Rin Acute Myeloid Leukemia
Previous gene function analyses have indicated that HOXA9, DEK, CBL and CSF1R are aberrantly expressed in acute myeloid leukemia (AML). We analyzed the expression of these genes in a series of 41 adult patients with AML using quantitative real-time RT-PCR, and tested the association of the expression with the following hematologic and clinical parameters: age, FAB, immunophenotype and karyotype aberrations. A high proportion of the patients showed over- or underexpression of the analyzed genes. DEK was overexpressed in 98% of the cases, whereas CBL, CSF1R and HOXA9 were either overexpressed in 20%, 17% and 78% or underexpressed in 20%, 42% and 15% of the cases, respectively. Patients whose karyotype contained t(8;21)(q22;q22), showed lower relative expression of HOXA9 at a statistically significant level (p < 0.05). Bone marrow samples without expression of CD34 antigen were associated with either overexpression of DEK or HOXA9. Furthermore, an association was found between the AML-M2 subtype and lower expression of CBL, CSF1R or HOXA9, and between the AML-M5 subtype and CBL or CSF1R overexpression.
- National University of La Plata Argentina
- University of Helsinki Finland
- National University of La Pampa Argentina
- Autonomous University of Barcelona Spain
- Helsinki University Hospital Finland
Acute Myeloid Leukemia, Adult, Male, Chromosomal Proteins, Non-Histone, Chromosomes, Human, Pair 21, Gene Expression, Immunophenotyping, Antigens, CD, BIOLOGIA, Array-based Methods, Humans, Poly-ADP-Ribose Binding Proteins, Aged, Homeodomain Proteins, Oncogene Proteins, Gene Expression Regulation, Leukemic, Middle Aged, Oncogene Protein v-cbl, Quantitative Real-time Rt-PCR, Neoplasm Proteins, Leukemia, Myeloid, Karyotyping, Acute Disease, Female, Chromosomes, Human, Pair 8
Acute Myeloid Leukemia, Adult, Male, Chromosomal Proteins, Non-Histone, Chromosomes, Human, Pair 21, Gene Expression, Immunophenotyping, Antigens, CD, BIOLOGIA, Array-based Methods, Humans, Poly-ADP-Ribose Binding Proteins, Aged, Homeodomain Proteins, Oncogene Proteins, Gene Expression Regulation, Leukemic, Middle Aged, Oncogene Protein v-cbl, Quantitative Real-time Rt-PCR, Neoplasm Proteins, Leukemia, Myeloid, Karyotyping, Acute Disease, Female, Chromosomes, Human, Pair 8
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