The putative functional rs1045881 marker of neurexin-1 in schizophrenia and clozapine response
Copyright policy )The putative functional rs1045881 marker of neurexin-1 in schizophrenia and clozapine response
Neurexin-1 (NRXN1) modulates recruitment of NMDA receptors. Furthermore, clozapine reduces hyperactivity of NMDA receptors. Thus, regulation of the NRXN1 gene may mediate the efficacy of clozapine at reducing cortical hyperactivity. We examined the putative functional SNP, rs1045881, for association with schizophrenia, and the potential role of this SNP in clozapine response. The rs1045881 variant was not significantly associated with schizophrenia (N=302 case-control pairs), but with clozapine response (N=163; p=0.030). Baseline and BPRS scores after six months revealed a trend for rs1045881 genotype by treatment interaction (p=0.079). In the post hoc analysis, a significant association between BPRS negative symptoms score and genotype was observed (p=0.033). These results suggest that the rs1045881 NRXN1 polymorphism may influence clozapine response.
- Centre for Addiction and Mental Health Canada
- Vanderbilt University United States
- King’s University United States
- Columbia University United States
- University of California, Irvine United States
Male, Psychiatric Status Rating Scales, Analysis of Variance, Time Factors, Genotype, Cell Adhesion Molecules, Neuronal, Calcium-Binding Proteins, Nerve Tissue Proteins, Polymorphism, Single Nucleotide, White People, Gene Frequency, Pharmacogenetics, Case-Control Studies, Schizophrenia, Humans, Female, Clozapine, Neural Cell Adhesion Molecules, Antipsychotic Agents
Male, Psychiatric Status Rating Scales, Analysis of Variance, Time Factors, Genotype, Cell Adhesion Molecules, Neuronal, Calcium-Binding Proteins, Nerve Tissue Proteins, Polymorphism, Single Nucleotide, White People, Gene Frequency, Pharmacogenetics, Case-Control Studies, Schizophrenia, Humans, Female, Clozapine, Neural Cell Adhesion Molecules, Antipsychotic Agents
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