Total synthesis of muconin

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Nov 2002 English Publisher:Elsevier BVJournal:Tetrahedron Letters, volume 43, pages 8,661-8,664 (issn: 0040-4039,

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Authors: Shunya Takahashi; Akemi Kubota; Tadashi Nakata;

doi: 10.1016/s0040-4039(02)02182-2 , 10.1002/chin.200307188

Total synthesis of muconin

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Abstract

Abstract An antitumor acetogenin, muconin, was synthesized through a coupling reaction of a THF–THP segment and a terminal butenolide. The key reactions include 6- exo cyclization of an epoxy tetraol, regioselective cyclization of hydroxy tosylate, and stereoselective reduction of an acyclic ketone adjacent to the 2,6- cis THP ring with Zn(BH 4 ) 2 .

Related Organizations

Saitama University
Japan
RIKEN
Japan

5 Research products, page 1 of 1

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