A Cdc20-APC Ubiquitin Signaling Pathway Regulates Presynaptic Differentiation
Copyright policy )A Cdc20-APC Ubiquitin Signaling Pathway Regulates Presynaptic Differentiation
Cdc20-APC in Synapse Formation The E3 ubiquitin ligase Cdc20-anaphase promoting complex (Cdc20-APC) has important roles in the control of the cell division cycle. Yang et al. (p. 575 ) now show that Cdc20-APC also appears to be required for proper formation of synapses by developing neurons in the rat brain. When Cdc20-APC was depleted from cultured neurons or in the brains of developing rat pups, synapse formation was inhibited. The brain-enriched transcription factor NeuroD2 was shown to be a possible target of Cdc20-APC–stimulated degradation. NeuroD2 may act by promoting synthesis of Complexin II, a protein that regulates synaptic vesicle fusion.
- Brigham and Women's Faulkner Hospital United States
- Harvard University United States
Cdc20 Proteins, Ubiquitin, Neuropeptides, Presynaptic Terminals, Ubiquitin-Protein Ligase Complexes, Cell Cycle Proteins, Nerve Tissue Proteins, Synapsins, Anaphase-Promoting Complex-Cyclosome, Axons, Rats, Adaptor Proteins, Vesicular Transport, Cerebellar Cortex, Gene Knockdown Techniques, Synapses, Basic Helix-Loop-Helix Transcription Factors, Animals, Mutant Proteins, Synaptic Vesicles, Signal Transduction
Cdc20 Proteins, Ubiquitin, Neuropeptides, Presynaptic Terminals, Ubiquitin-Protein Ligase Complexes, Cell Cycle Proteins, Nerve Tissue Proteins, Synapsins, Anaphase-Promoting Complex-Cyclosome, Axons, Rats, Adaptor Proteins, Vesicular Transport, Cerebellar Cortex, Gene Knockdown Techniques, Synapses, Basic Helix-Loop-Helix Transcription Factors, Animals, Mutant Proteins, Synaptic Vesicles, Signal Transduction
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).109 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!