Adult-Onset Alopecia Areata Is a Complex Polygenic Trait in the C3H/HeJ Mouse Model
Copyright policy )Adult-Onset Alopecia Areata Is a Complex Polygenic Trait in the C3H/HeJ Mouse Model
Alopecia areata (AA) is an autoimmune disease that targets actively growing (anagen) hair follicles in humans and other mammals. C3H/HeJ, but not C57BL/6J, mice spontaneously develop an adult-onset form of AA. A segregating population of C3HB6F2 female mice (n=1096), generated from crossing these two strains, was used for genome-wide linkage analysis to identify AA genetic susceptibility. Previous analysis identified susceptibility intervals on chromosomes 17 (Alaa1) and 9 (Alaa2). Using additional markers in these intervals and saturation mapping purported intervals on chromosomes 8 and 15, two additional regions were identified (Alaa3 and Alaa4, respectively). Human gene association studies identified specific human leukocyte antigen intervals comparable with those (major histocompatibility complex) found in Alaa1 in the mouse. Other human studies identified genes not found in this linkage study, but these human transcription factors are directly regulated by genes within Alaa1. These results indicate the necessity of integrating both gene association and genome-wide linkage studies in both mice and humans to understand the complex nature of these and other polygenic diseases.
- Vanderbilt University Medical Center United States
- Jackson Laboratory United States
Genetic Markers, Male, 570, Multifactorial Inheritance, Major-Histocompatibility-Complex, Alopecia Areata, Genotype, 610, Alaa1, autoimmune disease, Alaa2, Dermatology, Alaa3, Biochemistry, Major Histocompatibility Complex, Multifactorial-Inheritance, Mice, Animals, Humans, mouse models, Genetic Predisposition to Disease, Mice-Inbred-C3H, Age of Onset, Molecular Biology, Alopecia-Areata, Mice, Inbred C3H, Genetic-Markers, Genetic-Predisposition-to-Disease, Mice-Inbred-C57BL, Chromosome Mapping, Cell Biology, HLA, Mice, Inbred C57BL, Disease Models, Animal, Alaa4, Chromosome-Mapping, H2, Female, Disease-Models-Animal, Human
Genetic Markers, Male, 570, Multifactorial Inheritance, Major-Histocompatibility-Complex, Alopecia Areata, Genotype, 610, Alaa1, autoimmune disease, Alaa2, Dermatology, Alaa3, Biochemistry, Major Histocompatibility Complex, Multifactorial-Inheritance, Mice, Animals, Humans, mouse models, Genetic Predisposition to Disease, Mice-Inbred-C3H, Age of Onset, Molecular Biology, Alopecia-Areata, Mice, Inbred C3H, Genetic-Markers, Genetic-Predisposition-to-Disease, Mice-Inbred-C57BL, Chromosome Mapping, Cell Biology, HLA, Mice, Inbred C57BL, Disease Models, Animal, Alaa4, Chromosome-Mapping, H2, Female, Disease-Models-Animal, Human
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).60 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!