Mapping of the Genes Encoding Mouse Thromboxane A2 Receptor and Prostaglandin E Receptor Subtypes EP2 and EP3
Copyright policy )Mapping of the Genes Encoding Mouse Thromboxane A2 Receptor and Prostaglandin E Receptor Subtypes EP2 and EP3
Thromboxane A2 (TXA2) and prostaglandin E2 (PGE2) are two of the most representative eicosanoids that are formed from arachidonic acid. They produce a broad spectrum of biological effects mediated through specific cell surface receptors. We have mapped genetic loci for TXA2 receptor, Tbxa2r, and for PGE2 receptor subtypes EP2 and EP3, Ptgerep2 and Ptgerep3, respectively, using restriction fragment length variants in interspecific backcross mice. None of the three loci cosegregated with each other. Tbxa2r mapped to Chr 10, Ptgerep2 mapped to the distal end of Chr 3. Possible human loci for these receptors are predicted based on the homology between mouse and human chromosomes.
- Duke University United States
- Duke University Hospital United States
- Kyoto University Japan
- Duke Medical Center United States
- Duke University Health System United States
Male, Mice, Inbred C3H, Receptors, Thromboxane, Chromosome Mapping, Sequence Homology, Muridae, Mice, Genes, Haplotypes, Species Specificity, Animals, Humans, Hybridization, Genetic, Receptors, Prostaglandin E, Female, Crosses, Genetic, Polymorphism, Restriction Fragment Length
Male, Mice, Inbred C3H, Receptors, Thromboxane, Chromosome Mapping, Sequence Homology, Muridae, Mice, Genes, Haplotypes, Species Specificity, Animals, Humans, Hybridization, Genetic, Receptors, Prostaglandin E, Female, Crosses, Genetic, Polymorphism, Restriction Fragment Length
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