Underexpression of C-myc in Adrenocortical Cancer: A Major Pathogenic Event?
Copyright policy )Underexpression of C-myc in Adrenocortical Cancer: A Major Pathogenic Event?
The protooncogene c-myc is a major factor in tumourigenesis. Whereas c-myc overexpression is considered to be a general feature of many tumours, we have recently demonstrated c-myc underexpression in adrenocortical cancer by a meta-analysis. We hypothesise that c-myc underexpression might be a central event in adrenortical tumourigenesis based on network topology modelling and previous experimental observations. In this brief hypothesis, we present our arguments and their possible relevance.
- Semmelweis University Hungary
Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins c-myc, Humans, Gene Regulatory Networks, Adrenal Cortex Neoplasms
Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins c-myc, Humans, Gene Regulatory Networks, Adrenal Cortex Neoplasms
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