A Concise and Modular Synthesis of Pyranicin

descriptionPublicationkeyboard_double_arrow_right Article 10 Oct 2008 English Publisher:American Chemical Society (ACS)Journal:Organic Letters, volume 10, pages 4,955-4,957 (issn: 1523-7060, eissn: 1523-7052,

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Authors: Nolan D, Griggs; Andrew J, Phillips;

doi: 10.1021/ol802041c

pmid: 18844364

pmc: PMC2901595

A Concise and Modular Synthesis of Pyranicin

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Abstract

A modular, 13-step synthesis of the tetrahydropyran-containing annonaceous acetogenin pyranicin is reported. Key features are the use of an Achmatowicz oxidation-Kishi reduction sequence for the assembly of a pyranone from a furan and the application of Fu's alkyl-alkyl Suzuki coupling for subunit union.

Related Organizations

University of Colorado Boulder
United States

Keywords

Lactones, 4-Butyrolactone, Molecular Structure, Furans

4 Research products, page 1 of 1

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