AUGMENTED EXPRESSION OF THE ENDOTHELIN‐A RECEPTOR GENE IN CULTURED MESANGIAL CELLS FROM STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS
Copyright policy )AUGMENTED EXPRESSION OF THE ENDOTHELIN‐A RECEPTOR GENE IN CULTURED MESANGIAL CELLS FROM STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS
Summary1. To elucidate the role of endothelin (ET) receptor in hypertension, we studied the expression of the ET‐A receptor (ET‐ AR) gene and the ET‐B receptor (ET‐BR) gene in cultured mesangial cells isolated from stroke‐prone spontaneously hypertensive rats (SHRSP) and Wistar‐Kyoto (WKY) rats.2. The mesangial cells from both SHRSP and WKY expressed ET‐AR predominantly. The level of the ET‐AR mRNA in mesangial cells from SHRSP was 5‐fold higher than that in the cells from WKY. The ET‐BR mRNA in the mesangial cells from both strains was hardly detectable by northern blot analysis.3. These results demonstrate that the expression of the ET‐AR gene was markedly augmented in mesangial cells from SHRSP.
- Kyoto University Japan
Cerebrovascular Disorders, Receptors, Endothelin, Rats, Inbred SHR, Hypertension, Animals, Blotting, Northern, Rats, Inbred WKY, Cells, Cultured, Glomerular Mesangium, Rats
Cerebrovascular Disorders, Receptors, Endothelin, Rats, Inbred SHR, Hypertension, Animals, Blotting, Northern, Rats, Inbred WKY, Cells, Cultured, Glomerular Mesangium, Rats
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