The α(1,3)Fucosyltransferase Fuc-TVII Controls Leukocyte Trafficking through an Essential Role in L-, E-, and P-selectin Ligand Biosynthesis
Copyright policy )The α(1,3)Fucosyltransferase Fuc-TVII Controls Leukocyte Trafficking through an Essential Role in L-, E-, and P-selectin Ligand Biosynthesis
alpha(1,3)Fucosylated oligosaccharides represent components of leukocyte counterreceptors for E- and P-selectins and of L-selectin ligands expressed by lymph node high endothelial venules (HEV). The identity of the alpha(1,3)fucosyltransferase(s) required for their expression has been uncertain, as has a requirement for alpha(1,3)fucosylation in HEV L-selectin ligand activity. We demonstrate here that mice deficient in alpha(1,3) fucosyltransferase Fuc-TVII exhibit a leukocyte adhesion deficiency characterized by absent leukocyte E- and P-selectin ligand activity and deficient HEV L-selectin ligand activity. Selectin ligand deficiency is distinguished by blood leukocytosis, impaired leukocyte extravasation in inflammation, and faulty lymphocyte homing. These observations demonstrate an essential role for Fuc-TVII in E-, P-, and L-selectin ligand biosynthesis and imply that this locus can control leukocyte trafficking in health and disease.
- Harvard University United States
- University of Michigan–Flint United States
- Howard Hughes Medical Institute United States
- Department of Pathology Taiwan
- Howard Hughes Medical Institute
Mice, Knockout, Glycosylation, Biochemistry, Genetics and Molecular Biology(all), Leukocytosis, Neutrophils, Fucosyltransferases, Ligands, Mice, P-Selectin, Cell Movement, Antigens, Surface, Cell Adhesion, Immunologic Techniques, Animals, Endothelium, Vascular, Lymphocytes, L-Selectin, E-Selectin, Protein Processing, Post-Translational, Cells, Cultured
Mice, Knockout, Glycosylation, Biochemistry, Genetics and Molecular Biology(all), Leukocytosis, Neutrophils, Fucosyltransferases, Ligands, Mice, P-Selectin, Cell Movement, Antigens, Surface, Cell Adhesion, Immunologic Techniques, Animals, Endothelium, Vascular, Lymphocytes, L-Selectin, E-Selectin, Protein Processing, Post-Translational, Cells, Cultured
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