Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues
Copyright policy ) Mark D, Rosen; Hariharan, Venkatesan; Hillary M, Peltier; Scott D, Bembenek; Kimon C, Kanelakis; Lucy X, Zhao; Barry E, Leonard; +13 Authors
Mark D, Rosen; Hariharan, Venkatesan; Hillary M, Peltier; Scott D, Bembenek; Kimon C, Kanelakis; Lucy X, Zhao; Barry E, Leonard; Frances M, Hocutt; Xiaodong, Wu; Heather L, Palomino; Theresa I, Brondstetter; Peter V, Haugh; Laurence, Cagnon; Wen, Yan; Lisa A, Liotta; Andrew, Young; Tara, Mirzadegan; Nigel P, Shankley; Terrance D, Barrett; Michael H, Rabinowitz;
Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues
HIF prolyl 4-hydroxylases (PHD) are a family of enzymes that mediate key physiological responses to hypoxia by modulating the levels of hypoxia inducible factor 1-α (HIF1α). Certain benzimidazole-2-pyrazole carboxylates were discovered to be PHD2 inhibitors using ligand- and structure-based methods and found to be potent, orally efficacious stimulators of erythropoietin secretion in vivo.
- Johnson & Johnson (United States) United States
- Johnson & Johnson Pharmaceutical Research and Development China (People's Republic of)
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selected citations
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These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 62
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