High proportion of CD34+/CD38−cells is positively correlated with poor prognosis in newly diagnosed childhood acute lymphoblastic leukemia
Copyright policy )High proportion of CD34+/CD38−cells is positively correlated with poor prognosis in newly diagnosed childhood acute lymphoblastic leukemia
The CD34+/CD38- immunophenotype is used to identify candidate hematopoietic stem cells (HSCs) and leukemia-initiating cells (LICs). However, the clinical significance of the CD34+/CD38-proportion in childhood acute lymphoblastic leukemia (ALL) is not well established. Here, we found that a high proportion of CD34+/CD38- cells from 112 patients with childhood ALL was negatively correlated with the outcome. Also the percentage of CD34+/CD38- cells was associated with clinical and biological features of patients with ALL. Further, a high proportion of CD34+/CD38- cells in childhood ALL was positively correlated with advanced risk subgroups, which could predict risk stratification by receiver operating characteristic (ROC) curve analysis. In addition, a larger tumor burden and lower survival rate were observed in mice injected with CD34+/CD38- cells, but not in mice injected with other fractions. Our data reveal that a high proportion of CD34+/CD38- cells is positively associated with a poor prognosis of childhood ALL, to further guide therapy of the disease.
- Chongqing Medical University China (People's Republic of)
Male, Adolescent, Infant, Newborn, Infant, Antigens, CD34, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Prognosis, ADP-ribosyl Cyclase 1, Immunophenotyping, Disease Models, Animal, Mice, Phenotype, Child, Preschool, Neoplastic Stem Cells, Animals, Heterografts, Humans, Female, Child
Male, Adolescent, Infant, Newborn, Infant, Antigens, CD34, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Prognosis, ADP-ribosyl Cyclase 1, Immunophenotyping, Disease Models, Animal, Mice, Phenotype, Child, Preschool, Neoplastic Stem Cells, Animals, Heterografts, Humans, Female, Child
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