Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma
Copyright policy )Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma
We performed a mutational analysis of the 19 disintegrin-metalloproteinases (ADAMs) genes in human cutaneous metastatic melanoma and identified eight to be somatically mutated in 79 samples, affecting 34% of the melanoma tumors analyzed. Functional analysis of the two frequently mutated ADAM genes, ADAM29 and ADAM7 demonstrated that the mutations affect adhesion of melanoma cells to specific extracellular matrix proteins and in some cases increase their migration ability. This suggests that mutated ADAM genes could play a role in melanoma progression.
- Howard Hughes Medical Institute United States
- National Institute of Health Pakistan
- National Institutes of Health United States
- National Cancer Institute United States
- National Human Genome Research Institute United States
Adult, Male, Extracellular Matrix Proteins, Membrane Glycoproteins, Adolescent, DNA Mutational Analysis, Middle Aged, Skin Diseases, ADAM Proteins, Cell Movement, Mutation, Cell Adhesion, Humans, Female, Neoplasm Metastasis, Melanoma
Adult, Male, Extracellular Matrix Proteins, Membrane Glycoproteins, Adolescent, DNA Mutational Analysis, Middle Aged, Skin Diseases, ADAM Proteins, Cell Movement, Mutation, Cell Adhesion, Humans, Female, Neoplasm Metastasis, Melanoma
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