Cockayne Syndrome B protein (CSB): Linking p53, HIF-1 and p300 to robustness, lifespan, cancer and cell fate decisions
Copyright policy )Cockayne Syndrome B protein (CSB): Linking p53, HIF-1 and p300 to robustness, lifespan, cancer and cell fate decisions
Our recent data demonstrate that the CSB protein, besides its role in DNA repair, functions also as a master switch factor that can selectively influence the transcription of specific sets of genes, after DNA damage or hypoxia, by influencing the biological functions of p53. It is likely that the CSB protein, by modulating p53 activity after different cellular stresses would re-equilibrate the physiological response towards cell proliferation and survival instead of cell cycle arrest and cell death. Some important implications of these findings are discussed here.
- Imperial College London United Kingdom
- MRC London Institute of Medical Sciences United Kingdom
Cell Death, DNA Repair, Cell Survival, DNA Helicases, DNA Repair Enzymes, Neoplasms, Humans, Hypoxia-Inducible Factor 1, Tumor Suppressor Protein p53, Poly-ADP-Ribose Binding Proteins, E1A-Associated p300 Protein, Cell Proliferation, DNA Damage
Cell Death, DNA Repair, Cell Survival, DNA Helicases, DNA Repair Enzymes, Neoplasms, Humans, Hypoxia-Inducible Factor 1, Tumor Suppressor Protein p53, Poly-ADP-Ribose Binding Proteins, E1A-Associated p300 Protein, Cell Proliferation, DNA Damage
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