Genetic analyses of thiopurine methyltransferase polymorphisms in Greenlandic and Danish populations

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2006 English Publisher:WileyJournal:Acta Paediatrica, volume 95, pages 1,665-1,667 (issn: 0803-5253, eissn: 1651-2227,

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Authors: Nina, Toft; Ulrikka, Nygaard; Jannie, Gregers; Kjeld, Schmiegelow;

doi: 10.1080/08035250600743788

pmid: 17129980

Genetic analyses of thiopurine methyltransferase polymorphisms in Greenlandic and Danish populations

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Abstract

Abstract Aim: To determine the frequency of thiopurine methyltransferase (TPMT) low‐activity alleles in the Greenlandic and Danish populations. Methods: 142 Greenlandic individuals and 200 Danish blood donors were screened for the TPMT G460A and A719G low‐activity alleles. Results: Thiopurine methyltransferase low‐activity alleles were significantly higher in the Greenlandic compared to the Danish population, being 8.1% (95% CI 4.9–11.3) and 3.5% (95% CI 1.7–5.3) (p<0.01), respectively. Except for one Danish patient with an A719G allele (TPMT*3C), all the aberrant alleles were compound G460A and A719G alleles (TPMT*3A). Conclusion: In the Danish population, the incidence of thiopurine methyltransferase low‐activity alleles was found to be similar to other Caucasian populations previously described. In contrast, the Greenlandic population showed a significantly higher frequency of thiopurine methyltransferase low‐activity alleles.

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Keywords

Adult, Aged, 80 and over, Male, Polymorphism, Genetic, Adolescent, Denmark, Greenland, Methyltransferases, Middle Aged, Genetics, Population, Humans, Female, Alleles, Aged

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