
pmid: 10640715
We have isolated full-length cDNAs of chick Chx10 and Chx10-1, two members of the paired type homeobox/CVC gene family. A comparison of sequences suggests that Chx10 is closely related to Alx/Vsx-2 and Vsx-2 of zebrafish and goldfish, respectively; while Chx10-1 is closely related to Vsx-1 of zebrafish and goldfish. Chx10 and Chx10-1 are expressed in the early retinal neuroepithelium, but not in the pigment epithelium and lens. The expression of Chx10 is present in most retinal neuroblasts, while Chx10-1 exhibits a novel pattern along the nasotemporal border. In the differentiating retina, both Chx10 and Chx10-1 are restricted to bipolar cells and are maintained at a low level in bipolar cells of the mature retina.
Homeodomain Proteins, Embryology, Sequence Homology, Amino Acid, Molecular Sequence Data, Gene Expression, Chick Embryo, Retina, Avian Proteins, Animals, Tissue Distribution, Amino Acid Sequence, Eye Proteins, Developmental Biology, Transcription Factors
Homeodomain Proteins, Embryology, Sequence Homology, Amino Acid, Molecular Sequence Data, Gene Expression, Chick Embryo, Retina, Avian Proteins, Animals, Tissue Distribution, Amino Acid Sequence, Eye Proteins, Developmental Biology, Transcription Factors
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