No Evidence of rVSV-Ebola Virus Vaccine Replication or Dissemination in the Sand Fly Phlebotomus papatasi
Copyright policy )No Evidence of rVSV-Ebola Virus Vaccine Replication or Dissemination in the Sand Fly Phlebotomus papatasi
Following vaccination with the live attenuated, recombinant vesicular stomatitis virus Indiana serotype Ebola virus (rVSV-EBOV) vaccine, persons may exhibit a transient vaccine-associated viremia. To investigate the potential for Old World sand flies to transmit this vaccine following feeding on a viremic person, we fed laboratory-reared Phlebotomus papatasi an artificial blood meal containing 7.2 log10 plaque-forming units of rVSV-EBOV. Replication or dissemination was not detected in the body or legs of any P. papatasi collected at seven (n = 75) or 15 (n = 75) days post-feed. These results indicate a low potential for rVSV-EBOV to replicate and disseminate in P. papatasi, a species whose geographic distribution ranges from Morocco to southwest Asia and as far north as southern Europe.
- National Museum of Natural History United States
- Smithsonian Institution United States
- Walter Reed Army Institute of Research United States
- United States Army Medical Research Institute of Infectious Diseases United States
Phlebotomus, Disease Transmission, Infectious, Animals, Humans, Ebola Vaccines, Hemorrhagic Fever, Ebola, Antibodies, Viral, Ebolavirus
Phlebotomus, Disease Transmission, Infectious, Animals, Humans, Ebola Vaccines, Hemorrhagic Fever, Ebola, Antibodies, Viral, Ebolavirus
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