2-haloethanols: Mutagenicity and reactivity with DNA

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1974 English Publisher:Elsevier BVJournal:Mutation Research, volume 26, pages 367-370 (issn: 0027-5107,

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Authors: S, Rosenkranz; H S, Carr; H S, Rosenkranz;

doi: 10.1016/s0027-5107(74)80002-3

pmid: 4607366

2-haloethanols: Mutagenicity and reactivity with DNA

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Abstract

Summary Iodo-, bromo- and chloroethanol are mutagenic for Salmonella typhimuriurn . The mutations induced are of the base-substitution type. These haloethanols also preferentially inhibit the growth of DNA polymerase-deficient Escherichia coli . The order of the reactivities of the substances in these systems is bromoethanol > iodoethanol > chloroethanol. These alcohols react with and modify isolated DNA.

Related Organizations

King’s University
United States
Columbia University
United States

Keywords

DNA, Bacterial, Salmonella typhimurium, Base Sequence, Ethanol, DNA, Thymus Gland, Halogens, DNA Nucleotidyltransferases, Mutation, Escherichia coli, Animals, Cattle, Mutagens

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