Expression of VEGF and VEGF Receptors in Childhood Precursor B-cell Acute Lymphoblastic Leukemia Evaluated by Immunohistochemistry
Copyright policy )Expression of VEGF and VEGF Receptors in Childhood Precursor B-cell Acute Lymphoblastic Leukemia Evaluated by Immunohistochemistry
Perturbation in the expression and signaling pathways of vascular endothelial growth factor (VEGF) has been linked to pathogenesis of hematologic malignancies. We investigated the expression and clinical importance of VEGF and two of its receptors, VEGFR-1 and VEGFR-2, in childhood precursor B-cell acute lymphoblastic leukemia (pre-B ALL) by using immunohistochemistry. These angiogenic proteins were expressed in the majority of leukemic bone marrow samples. Notably, pre-B ALL patients had significantly increased expression of VEGFR-1 compared with no expression in the nonmalignant group, indicating a link between VEGFR-1 protein expression and pre-B ALL. These novel findings suggest that VEGFR-1 may have clinical importance in childhood pre-B ALL.
- Karolinska Institute Sweden
- Lund University Sweden
- Malmö University Sweden
- Karolinska University Hospital Sweden
- Linköping University Hospital Sweden
Male, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factor Receptor-1, Adolescent, Neovascularization, Pathologic, Gene Expression Regulation, Leukemic, Infant, Prognosis, Vascular Endothelial Growth Factor Receptor-2, Neoplasm Proteins, Immunoenzyme Techniques, Bone Marrow, Child, Preschool, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Humans, Female, Child, Follow-Up Studies
Male, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factor Receptor-1, Adolescent, Neovascularization, Pathologic, Gene Expression Regulation, Leukemic, Infant, Prognosis, Vascular Endothelial Growth Factor Receptor-2, Neoplasm Proteins, Immunoenzyme Techniques, Bone Marrow, Child, Preschool, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Humans, Female, Child, Follow-Up Studies
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