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Warfarin pharmacodynamics and pharmacokinetics are not affected by the soluble guanylate cyclase stimulator riociguat (BAY 63-2521)

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Aug 2009 English Publisher:Springer Science and Business Media LLCJournal:BMC Pharmacology, volume 9 (eissn: 1471-2210, Copyright policy )
Authors: Gerrit Weimann; Georg Wensing; Nina Kirschbaum; Wolfgang Mück; Jörn Krätzschmar; Reiner Frey;

doi: 10.1186/1471-2210-9-s1-p15

Warfarin pharmacodynamics and pharmacokinetics are not affected by the soluble guanylate cyclase stimulator riociguat (BAY 63-2521)

Abstract

Background Pulmonary hypertension (PH) is a progressive and debilitating condition with a high rate of mortality. Riociguat (BAY 63-2521) is a new drug in development for PH that is well tolerated [1,2] and has superior efficacy to nitric oxide in patients with PH [2]. Treatment recommendations for PH are based on combination therapies that include warfarin. The aim of this study was to investigate potential pharmacodynamic or pharmacokinetic interactions of riociguat and warfarin.

Keywords

Pharmacology, Poster Presentation, Pharmacology (medical)

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
3
Average
Average
Average
Green
gold
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