HLA‐B*5808, a new HLA‐B allele characterized by sequence based typing
Copyright policy )HLA‐B*5808, a new HLA‐B allele characterized by sequence based typing
Abstract: This brief communication describes a new HLA‐B allele (HLA‐B*5808) detected in an Italian white volunteer bone marrow donor. With serology, this subject was typed as HLA‐B15,17, whereas with molecular biology B*15, B*51, B*52 and/or B*58 could be assigned. In order to clarify the results, direct and cloning sequencing of exons 2, 3 and 4 were carried out. This new allele is identical to HLA‐B*5801 in exon 2 except for a silent point mutation at nucleotide 141 where a C is substituted by a T; exons 3 and 4 are typical of HLA‐B*51, B*52 and B*78. The peculiar sequence of B*5808 could explain the discrepancy between the serological and molecular typing results.
Amino Acid Substitution, Base Sequence, HLA-B Antigens, Molecular Sequence Data, Humans, Point Mutation, Amino Acid Sequence, Exons, Alleles
Amino Acid Substitution, Base Sequence, HLA-B Antigens, Molecular Sequence Data, Humans, Point Mutation, Amino Acid Sequence, Exons, Alleles
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