Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana
Copyright policy )Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana
The plant hormone auxin regulates diverse aspects of plant growth and development. We report that in Arabidopsis, auxin response is dependent on a ubiquitin-ligase (E3) complex called SCFTIR1. The complex consists of proteins related to yeast Skp1p and Cdc53p called ASK and AtCUL1, respectively, as well as the F-box protein TIR1. Mutations in either ASK1 or TIR1 result in decreased auxin response. Further, overexpression of TIR1 promotes auxin response suggesting that SCFTIR1 is limiting for the response. These results provide new support for a model in which auxin action depends on the regulated proteolysis of repressor proteins.
- Pennsylvania State University United States
- National Research Council Canada Canada
- The University of Texas at Austin United States
- Indiana University United States
- Indiana University Bloomington United States
proteolysis, SKP Cullin F-Box Protein Ligases, Indoleacetic Acids, TIR1, Arabidopsis Proteins, Recombinant Fusion Proteins, Molecular Sequence Data, Arabidopsis, SCF, Plant Roots, ubiquitin-ligase, Gene Expression Regulation, Plant, Amino Acid Sequence, Peptide Synthases, auxin, Sequence Alignment, Plant Proteins
proteolysis, SKP Cullin F-Box Protein Ligases, Indoleacetic Acids, TIR1, Arabidopsis Proteins, Recombinant Fusion Proteins, Molecular Sequence Data, Arabidopsis, SCF, Plant Roots, ubiquitin-ligase, Gene Expression Regulation, Plant, Amino Acid Sequence, Peptide Synthases, auxin, Sequence Alignment, Plant Proteins
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