Polymorphism of the CD36 Gene and Cardiovascular Risk Factors in Patients with Coronary Artery Disease Manifested at a Young Age
Copyright policy )Polymorphism of the CD36 Gene and Cardiovascular Risk Factors in Patients with Coronary Artery Disease Manifested at a Young Age
This study investigates potential associations between CD36 gene variants and the presence of risk factors in Caucasians with coronary artery disease (CAD) manifested at a young age. The study group consisted of 90 patients; the men were ≤ 50 years old and the women were ≤ 55 years old. Amplicons of exons 4 and 5 including fragments of introns were analyzed by DHPLC. Two polymorphisms were found: IVS3-6 T/C (rs3173798) and IVS4-10 G/A (rs3211892). The C allele of the IVS3-6 T/C polymorphism was associated with higher prevalence of obesity and diabetes, higher hsCRP, lower Lp(a) serum concentrations, and younger age at myocardial infarction. The A allele of the IVS4-10 G/A polymorphism was associated with older age of myocardial infarction and higher white blood cell count. The functional role of CD36 polymorphisms in CAD development needs further research.
- Pomeranian Medical University Poland
- Wrocław Medical University Poland
Adult, CD36 Antigens, Male, Polymorphism, Genetic, Myocardial Infarction, Coronary Artery Disease, Middle Aged, Biochemistry, Article, Leukocyte Count, Diabetes Mellitus, Type 2, Genetics, Humans, Female, Genetic Predisposition to Disease, Obesity, Poland, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Chromatography, High Pressure Liquid
Adult, CD36 Antigens, Male, Polymorphism, Genetic, Myocardial Infarction, Coronary Artery Disease, Middle Aged, Biochemistry, Article, Leukocyte Count, Diabetes Mellitus, Type 2, Genetics, Humans, Female, Genetic Predisposition to Disease, Obesity, Poland, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Chromatography, High Pressure Liquid
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