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Tax Induces the Recruitment of NF-κB to Unintegrated HIV-1 DNA To Rescue Viral Gene Expression and Replication

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 17 Feb 2021Publisher:American Society for MicrobiologyJournal:Journal of Virology, volume 95 (issn: 0022-538X, eissn: 1098-5514,

Copyright policy )Funded by:NIH | The Center for HIV RNA St..., NIH | Centers for AIDS Research..., NIH | Reversal of epigenetic si...

Authors: Ishak D. Irwan; Bryan R. Cullen;

doi: 10.1128/jvi.00285-21 , 10.1101/2021.02.16.431555

pmid: 33883218

pmc: PMC8315925

Tax Induces the Recruitment of NF-κB to Unintegrated HIV-1 DNA To Rescue Viral Gene Expression and Replication

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Abstract

Integrase-deficient expression vectors based on HIV-1 are becoming increasingly popular as tools for gene therapy in vivo due to their inability to cause insertional mutagenesis. However, many IN − lentiviral vectors are able to achieve only low levels of gene expression, and methods to increase this low level have not been extensively explored.

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Keywords

Gene Expression Regulation, Viral, Human T-lymphotropic virus 1, Virus Integration, NF-kappa B, Gene Expression, Gene Products, tax, HIV Integrase, Virus Replication, Cell Line, Enzyme Activation, HEK293 Cells, Proviruses, DNA, Viral, HIV-1, Humans, Promoter Regions, Genetic

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