A role for the EphA family in the topographic targeting of vomeronasal axons
Copyright policy )A role for the EphA family in the topographic targeting of vomeronasal axons
ABSTRACT We have investigated the role of the Eph family of receptor tyrosine kinases and their ligands in the establishment of the vomeronasal projection in the mouse. Our data show intriguing differential expression patterns of ephrin-A5 on vomeronasal axons and of EphA6 in the accessory olfactory bulb (AOB), such that axons with high ligand concentration project onto regions of the AOB with high receptor concentration and vice versa. These data suggest a mechanism for development of this projection that is the opposite of the repellent interaction between Eph receptors and ligands observed in other systems. In support of this idea, when given the choice of whether to grow on lanes containing EphA-Fc/laminin or Fc/laminin protein (in the stripe assay), vomeronasal axons prefer to grow on EphA- Fc/laminin. Analysis of ephrin-A5 mutant mice revealed a disturbance of the topographic targeting of vomeronasal axons to the AOB. In summary, these data, which are derived from in vitro and in vivo experiments, indicate an important role of the EphA family in setting up the vomeronasal projection.
- King's College London United Kingdom
- Max Planck Institute of Psychiatry Germany
- King's College London, University of London
- Max Planck Society Germany
- Max Planck Institute of Neurobiology Germany
Mice, Knockout, 500, Gene Expression Regulation, Developmental, Receptor Protein-Tyrosine Kinases, Receptor, EphA5, Mice, Transgenic, Olfactory Pathways, Receptor, EphA7, 540, beta-Galactosidase, Olfactory Bulb, Axons, Mice, Inbred C57BL, Embryonic and Fetal Development, Mice, Animals, Laminin, Vomeronasal Organ
Mice, Knockout, 500, Gene Expression Regulation, Developmental, Receptor Protein-Tyrosine Kinases, Receptor, EphA5, Mice, Transgenic, Olfactory Pathways, Receptor, EphA7, 540, beta-Galactosidase, Olfactory Bulb, Axons, Mice, Inbred C57BL, Embryonic and Fetal Development, Mice, Animals, Laminin, Vomeronasal Organ
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