Received April 30, 2013 Revised June 18, 2013 Accepted June 18, 2013 Address for correspondence Jae Wook Cho, MD Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, 20 Geumo-ro, Mulgeum-eup, Yangsan 626-770, Korea Tel: +82-55-360-2122 Fax: +82-55-360-2451 E-mail: sleep.cho@gmail.com Hypnic headache (HH) is a primary headache disorder occurring exclusively during sleep in the elderly. Although pathophysiology of HH is still unknown, the association with chronobiological perspective and rapid eye movement sleep has been suggested. Lithium has been reported to be the most effective drug for HH. However, its usage may be limited because of its toxicity. Indomethacin could be alternative treatment option, which has better safety profile. We report a case of HH, which was successfully treated with indomethacin. J Korean Sleep Res Soc 2013;10:31-33