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Uncovering Novel Cell Cycle Players Through the Inactivation of Securin in Budding Yeast

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2004 English Publisher:Oxford University Press (OUP)Journal:Genetics, volume 168, pages 1,763-1,771 (eissn: 1943-2631,

Authors: Orna Cohen-Fix; Lorrie Boucher; Sumeet Sarin; Mike Tyers; Karen E. Ross; Yvette Green;

doi: 10.1534/genetics.104.029033

pmid: 15579722

pmc: PMC1448791

Uncovering Novel Cell Cycle Players Through the Inactivation of Securin in Budding Yeast

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Abstract

Abstract Budding yeast securin/Pds1p, an inhibitor of the anaphase activator separase/Esp1p, is involved in several checkpoint pathways and in promoting Esp1p's nuclear localization. Using a modified synthetic genetic array (SGA) screen for genes that become essential in the absence of Pds1p, we uncovered roles for uncharacterized genes in cell cycle processes, including Esp1p activation.

Related Organizations

National Institutes of Health
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National Institute of Health
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Lunenfeld-Tanenbaum Research Institute
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University of Toronto
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Keywords

Securin, Saccharomyces cerevisiae Proteins, Cell Cycle, Saccharomycetales, Nuclear Proteins, Cell Cycle Proteins, Genes, Lethal

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26 Research products, page 1 of 3

Inner kinetochore subunit CTF19
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ATP-dependent DNA helicase CHL1
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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	26
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	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%