Novel evidence that pituitary gonadotropins directly stimulate human leukemic cells-studies of myeloid cell lines and primary patient AML and CML cells
Copyright policy )Novel evidence that pituitary gonadotropins directly stimulate human leukemic cells-studies of myeloid cell lines and primary patient AML and CML cells
We recently reported that normal hematopoietic stem cells express functional pituitary sex hormone (SexH) receptors. Here we report for the first time that pituitary-secreted gonadotrophins stimulate migration, adhesion, and proliferation of several human myeloid and lymphoid leukemia cell lines. Similar effects were observed after stimulation of human leukemic cell lines by gonadal SexHs. This effect seems to be direct, as the SexH receptors expressed by leukemic cells responded to stimulation by phosphorylation of MAPKp42/44 and AKTser473. Furthermore, in parallel studies we confirmed that human primary patient-derived AML and CML blasts also express several functional SexH receptors. These results shed more light on the potential role of SexHs in leukemogenesis and, in addition, provide further evidence suggesting a developmental link between hematopoiesis and the germline.
- Wrocław Medical University Poland
- Medical University of Białystok Poland
- Pomeranian Medical University Poland
- German Red Cross Germany
- University of Louisville United States
Cell movement - physiology, Białka proto-onkogenne c-akt - metabolizm, Folitropina - farmakologia, Signal transduction, Mitogen-activated protein kinases - metabolism, Lutropina - farmakologia, Receptory hormonów przysadki - metabolizm, Jurkat Cells, Cell Movement, Adhezja komórek - fizjologia, Receptors, Myeloid cells - metabolism, Myeloid Cells, Phosphorylation, Białaczka szpikowa przewlekła atopowa BCR-ABL-dodatnia - metabolizm, Leukemia, pituitary hormone - metabolism, acute - metabolism, Leukemia, Myeloid, Acute, Linie komórkowe nowotworowe, myeloid, Mitogen-Activated Protein Kinases, Research Paper, Signal Transduction, Fosforylacja, tumor, Luteinizing hormone - pharmacology, Follicle stimulating hormone - pharmacology, Ruch komórki - fizjologia, Transdukcja sygnału, Gonadotropiny przysadkowe - metabolizm, Cell Line, Tumor, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Cell Adhesion, Cell proliferation - physiology, Humans, Receptors, Pituitary Hormone, Kinazy MAP - metabolizm, Proto-oncogene proteins c-akt - metabolism, Cell Proliferation, Komórki Jurkat, Luteinizing Hormone, Cell adhesion - physiology, Jurkat cells, Proliferacja komórki, Gonadotropins, Pituitary, Leukemia myelogenous chronic BCR-ABL positive - metabolism, Gonadotropins pituitary - metabolism, Komórki mieloidalne, Follicle Stimulating Hormone, Cell line, Proto-Oncogene Proteins c-akt
Cell movement - physiology, Białka proto-onkogenne c-akt - metabolizm, Folitropina - farmakologia, Signal transduction, Mitogen-activated protein kinases - metabolism, Lutropina - farmakologia, Receptory hormonów przysadki - metabolizm, Jurkat Cells, Cell Movement, Adhezja komórek - fizjologia, Receptors, Myeloid cells - metabolism, Myeloid Cells, Phosphorylation, Białaczka szpikowa przewlekła atopowa BCR-ABL-dodatnia - metabolizm, Leukemia, pituitary hormone - metabolism, acute - metabolism, Leukemia, Myeloid, Acute, Linie komórkowe nowotworowe, myeloid, Mitogen-Activated Protein Kinases, Research Paper, Signal Transduction, Fosforylacja, tumor, Luteinizing hormone - pharmacology, Follicle stimulating hormone - pharmacology, Ruch komórki - fizjologia, Transdukcja sygnału, Gonadotropiny przysadkowe - metabolizm, Cell Line, Tumor, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Cell Adhesion, Cell proliferation - physiology, Humans, Receptors, Pituitary Hormone, Kinazy MAP - metabolizm, Proto-oncogene proteins c-akt - metabolism, Cell Proliferation, Komórki Jurkat, Luteinizing Hormone, Cell adhesion - physiology, Jurkat cells, Proliferacja komórki, Gonadotropins, Pituitary, Leukemia myelogenous chronic BCR-ABL positive - metabolism, Gonadotropins pituitary - metabolism, Komórki mieloidalne, Follicle Stimulating Hormone, Cell line, Proto-Oncogene Proteins c-akt
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).22 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!