Linkage relationships of X-linked choroideremia to DXYS1 and DXS3
Copyright policy )Linkage relationships of X-linked choroideremia to DXYS1 and DXS3
Choroideremia is a distinct blinding condition with an X-linked pattern of inheritance. We have analyzed two RFLPs, DXS3 and DXYS1, for linkage with the choroideremia locus (TCD) within three kindreds. A maximum LOD score of 3.98 was obtained at theta = 0.14 for TCD:DXS3. The summed maximum LOD score from this study and from previously published TCD:DXYS1 data is 5.23 at theta = 0.05. Contrary to previous reports, the present data demonstrate that these two RFLPs are not tightly linked to the choroideremia gene locus.
- Children's Hospital of Eastern Ontario Canada
- University of Ottawa Canada
Genetic Markers, Male, Polymorphism, Genetic, X Chromosome, Choroid, Genetic Linkage, Chromosome Mapping, Uveal Diseases, Pedigree, Humans, Female, Polymorphism, Restriction Fragment Length
Genetic Markers, Male, Polymorphism, Genetic, X Chromosome, Choroid, Genetic Linkage, Chromosome Mapping, Uveal Diseases, Pedigree, Humans, Female, Polymorphism, Restriction Fragment Length
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