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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Journal of Chromatog...arrow_drop_down
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Journal of Chromatography B Biomedical Sciences and Applications
Article . 1991 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
https://pubmed.ncbi.nlm.nih.go...
Article . 1991
Data sources: Europe PubMed Central
https://dx.doi.org/10.1016/037...
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High-performance liquid chromatographic determination of 18α-glycyrrhetinic acid and 18β-glycyrrhetinic acid in rat plasma: application to pharmacokinetic study

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1991 English Publisher:Elsevier BVJournal:Journal of Chromatography B: Biomedical Sciences and Applications, volume 567, pages 405-414 (issn: 0378-4347, Copyright policy )
Authors: T H, Tsai; C F, Chen;

doi: 10.1016/0378-4347(91)80146-4

pmid: 1658024

High-performance liquid chromatographic determination of 18α-glycyrrhetinic acid and 18β-glycyrrhetinic acid in rat plasma: application to pharmacokinetic study

Abstract

A high-performance liquid chromatographic method for the separation and determination of 18 alpha-glycyrrhetinic acid and 18 beta-glycyrrhetinic acid has been developed. Indomethacin was used as an internal standard. The drugs were separated on a reversed-phase column and detected by UV detection at a wavelength of 254 nm. Methanol-water-perchloric acid-ammonia (80:20:0.4:0.4, v/v) was used as the mobile phase at pH of 7.0-7.5. The detection limit of both compounds was 0.1 microgram/ml in rat plasma. The method was applied to pharmacokinetic studies of glycyrrhetinic acids in rats. The results suggest that the pharmacokinetics appeared to be non-linear in nature.

Related Organizations
Keywords

Male, Perchlorates, Rats, Inbred Strains, Hydrogen-Ion Concentration, Reference Standards, Rats, Ammonia, Animals, Glycyrrhetinic Acid, Spectrophotometry, Ultraviolet, Rabbits, Chromatography, High Pressure Liquid

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
31
Average
Top 10%
Top 10%
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