Characterization of a novel HLA‐Cw*02 variant, Cw*0208, in a Caucasian individual
Copyright policy )Characterization of a novel HLA‐Cw*02 variant, Cw*0208, in a Caucasian individual
Abstract: We describe an additional HLA‐Cw*02 variant, HLA‐Cw*0208, which has been identified in a renal transplant recipient of Caucasian origin (Italy). After performing preliminary serological typing, we analyzed exons 2 and 3 of the HLA‐C locus polymorphism by cloning the amplified DNA and using a sequence‐based typing method. The new allele differs from Cw*020202 by one nucleotide substitution at nucleotide 61 (G→A) of exon 2, which translates to a difference of one amino acid at residue 21 (His→Arg) of the HLA‐C heavy chain. We propose that Cw*0208 was generated by a random point mutation in codon 21 from the Cw*020202 allele, or through gene conversion of Cw*020202 with another allele, probably the Cw*1205 and Cw*1602 alleles.
- National Research Council Italy
- National Research Council Sri Lanka
- University of L'Aquila Italy
HLA-C; HLA-Cw*0208; new alleles; polymorph-ism; sequence-based typing; transplantation, Polymorphism, Genetic, Base Sequence, Sequence Homology, Amino Acid, Histocompatibility Testing, Molecular Sequence Data, Exons, HLA-C Antigens, Kidney Transplantation, Protein Structure, Secondary, Sequence Homology, Nucleic Acid, Humans, Point Mutation, Amino Acid Sequence, Amino Acids, Alleles
HLA-C; HLA-Cw*0208; new alleles; polymorph-ism; sequence-based typing; transplantation, Polymorphism, Genetic, Base Sequence, Sequence Homology, Amino Acid, Histocompatibility Testing, Molecular Sequence Data, Exons, HLA-C Antigens, Kidney Transplantation, Protein Structure, Secondary, Sequence Homology, Nucleic Acid, Humans, Point Mutation, Amino Acid Sequence, Amino Acids, Alleles
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