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Stage-Specific Differences in the Requirements for Germline Stem Cell Maintenance in the Drosophila Ovary

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2007 United States English Publisher:Elsevier BVJournal:Cell Stem Cell, volume 1, pages 698-709 (issn: 1934-5909, Copyright policy )
Authors: Halyna R. Shcherbata; Karin A. Fischer; Bruce A. Hay; Jenn Yah Yu; Chun-Hong Chen; Steven H. Reynolds; Peizhang Xu; +3 Authors

doi: 10.1016/j.stem.2007.11.007

pmid: 18213359

pmc: PMC2211735

handle: 11858/00-001M-0000-002D-1B95-F , 11858/00-001M-0000-002D-1B93-4

Stage-Specific Differences in the Requirements for Germline Stem Cell Maintenance in the Drosophila Ovary

Abstract

In this study, we uncover a role for microRNAs in Drosophila germline stem cell (GSC) maintenance. Disruption of Dicer-1 function in GSCs during adult life results in GSC loss. Surprisingly, however, loss of Dicer-1 during development does not result in a GSC maintenance defect, although a defect is seen if both Dicer-1 and Dicer-2 function are disrupted. Loss of the bantam microRNA mimics the Dicer-1 maintenance defect when induced in adult GSCs, suggesting that bantam plays a key role in GSC self-renewal. Mad, a component of the TGF-beta pathway, behaves similarly to Dicer-1: adult GSC maintenance requires Mad if it is lost during adult life, but not if it is lost during pupal development. Overall, these results show stage-specific differential sensitivity of GSC maintenance to certain perturbations, and suggest that there may be Dcr-2 dependent redundancy of GSC maintenance mechanisms during development that is lost in later life.

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Keywords

Ribonuclease III, Ovary, 590, G1 Phase, 610, Cell Biology, STEMCELL, S Phase, MicroRNAs, Germ Cells, Genetics, Molecular Medicine, Animals, Drosophila Proteins, Drosophila, Female, RNA Helicases, Signal Transduction

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
62
Top 10%
Top 10%
Top 10%
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