Synthesis and physical-chemical research of 7-((3-thio-4-r-4h-1,2,4-triazole-5-yl)methyl)theophylline carbonyl derivatives

descriptionPublicationkeyboard_double_arrow_right Article 15 Jun 2015Publisher:Zaporozhye State Medical UniversityJournal:Zaporozhye Medical Journal, volume 0 (issn: 2306-4145, eissn: 2310-1210,

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Authors: Gotsulia, A. S.; Knyazevich, P. S.; Panasenko, O. I.; Knysh, Ye. G.;

doi: 10.14739/2310-1210.2015.3.44510

Synthesis and physical-chemical research of 7-((3-thio-4-r-4h-1,2,4-triazole-5-yl)methyl)theophylline carbonyl derivatives

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Abstract

Aim. To analyze the carbonyl derivatives of 7-((3-thio-4-R-4H-1,2,4-triazole-5-yl)methyl)theophylline their mother substance was synthesized and its interaction with α-haloketones series was carried out. Methods and results. The physical-chemical properties of the obtained compounds have been studied and their structures have been confirmed by elemental analysis, infrared spectrometry, 1H NMR spectrometry, UV spectrophotometry and gas chromatography mass spectrometry. Preliminary computer study of acute toxicity and biological activity has been also carried out. It has been determined that the obtained compounds may exhibit diuretic and analeptic activity and 1,2,4-triazole fragment can theoretically increase it. Conclusion. Preliminary prediction of acute toxicity has showed that the compounds are low-toxic.

Keywords

1H NMR Spectrometry, 1, 4-триазол, 2, 1Н ЯМР-спектрометрия, R, теофиллин, ІЧ-спектрометрія, 1Н ЯМР- спектрометрія, Synthesis, синтез, теофілін, Theophylline, ИК-спектрометрия, 4-triazoles, IR Spectrometry, Medicine, 4-тріазол

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Synthesis and physical-chemical research of 7-((3-thio-4-r-4h-1,2,4-triazole-5-yl)methyl)theophylline carbonyl derivatives

Synthesis and physical-chemical research of 7-((3-thio-4-r-4h-1,2,4-triazole-5-yl)methyl)theophylline carbonyl derivatives

6 Research products, page 1 of 1

Synthesis and biological activity of (Z) and (E) isomers of 3-(3,4-diaryl-1,2,4-triazole-5-yl)prop-2-enoic acid

Establishment of diuretic activity indicators for (3-thio-4-R-4-H-1,2,4-triazole-5-yl)(phenyl)methanols and their derivatives

The study of the optical activity of some S-derivatives 4-R-5-((((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1, 2,4-triazole-3-thiols

The study of the optical activity of some S-derivatives 4-R-5-((((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1, 2,4-triazole-3-thiols

The study of 2-((3-R-4-R1-4H-1,2,4-triazole-5-yl)thio) acetic acid salts as growth stimulators of winter wheat sprouts

The study of antimicrobial and antifungal activity of Nʹ-ylidene-2(3-(adamantan-1-yl)-1H-1,2,4-triazole-5-yl)thioacetohydrazides