Cutting Edge: Antibody Production to Pneumococcal Polysaccharides Requires CD1 Molecules and CD8+ T Cells
Copyright policy )Cutting Edge: Antibody Production to Pneumococcal Polysaccharides Requires CD1 Molecules and CD8+ T Cells
Abstract T cell involvement in Ab responses to thymus-independent type 2 Ags is an immunologic enigma. The identity of these cells and the mechanisms of their TCR engagement to carbohydrate molecules remain unknown. We measured IgG Ab production after immunization with pneumococcal polysaccharides in mice with disruptions in selected genes of the T cell pathway. Nonclassical MHC class I-like CD1 molecules and MHC class I-dependent CD8+ cells were found to be essential. Our findings set forth a new paradigm for humoral responses in which CD1 expression as well as a subset of CD8+ cells are required to provide helper function for Ab production against thymus-independent type 2 polysaccharides, similar to MHC class II-restricted CD4+ cells for protein Ags.
- Harvard University United States
- Emory University United States
- Rockefeller University United States
Mice, Knockout, Antigen Presentation, Mice, Inbred BALB C, Polysaccharides, Bacterial, Antigen-Presenting Cells, CD8-Positive T-Lymphocytes, Antibodies, Bacterial, Antigens, T-Independent, Antigens, CD1, Mice, Inbred C57BL, Mice, Streptococcus pneumoniae, Immunoglobulin G, Animals
Mice, Knockout, Antigen Presentation, Mice, Inbred BALB C, Polysaccharides, Bacterial, Antigen-Presenting Cells, CD8-Positive T-Lymphocytes, Antibodies, Bacterial, Antigens, T-Independent, Antigens, CD1, Mice, Inbred C57BL, Mice, Streptococcus pneumoniae, Immunoglobulin G, Animals
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