p63 contributes to cell invasion and migration in squamous cell carcinoma of the head and neck
Copyright policy )p63 contributes to cell invasion and migration in squamous cell carcinoma of the head and neck
The transcription factor p63 is commonly over-expressed in squamous cell carcinomas of the head and neck (SCCHN). By microarray analysis of p63-siRNA-treated SCCHN cells we identified 127 genes whose expression relies on over-expression of p63. More than 20% of these genes are involved in cell motility. Chromatin immunoprecipitation and reporter assay revealed PAI-1 and AQP3 as direct p63 transcriptional targets. In addition to PAI-1, most of the key cell motility-related molecules are up-regulated by p63, such as MMP14 and LGALS1. Our findings indicate a contribution by p63 in cell invasion and migration, supporting an oncogenic role for p63 in SCCHN.
- University of Dundee United Kingdom
- Umeå University Sweden
Chromatin Immunoprecipitation, 572, Base Sequence, Reverse Transcriptase Polymerase Chain Reaction, Tumor Suppressor Proteins, 610, DNA-Binding Proteins, Head and Neck Neoplasms, Cell Line, Tumor, Carcinoma, Squamous Cell, Trans-Activators, Humans, Neoplasm Invasiveness, Neoplasm Metastasis, RNA, Small Interfering, Oligonucleotide Array Sequence Analysis, Transcription Factors
Chromatin Immunoprecipitation, 572, Base Sequence, Reverse Transcriptase Polymerase Chain Reaction, Tumor Suppressor Proteins, 610, DNA-Binding Proteins, Head and Neck Neoplasms, Cell Line, Tumor, Carcinoma, Squamous Cell, Trans-Activators, Humans, Neoplasm Invasiveness, Neoplasm Metastasis, RNA, Small Interfering, Oligonucleotide Array Sequence Analysis, Transcription Factors
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