Cloning, sequencing, and evolutionary analysis of the mouse erythropoietin gene.
Copyright policy )Cloning, sequencing, and evolutionary analysis of the mouse erythropoietin gene.
The gene for mouse erythropoietin was cloned and sequenced. We present here a preliminary analysis of the overall genomic organization of the coding portions and the two flanking regions of the gene. This is the third mammalian erythropoietin for which the sequence is available, but it represents the first from a nonprimate species. We investigated the evolutionary divergence of sequence and structure of the three erythropoietins and identified specific regions of the molecules that are apparently under various degrees, and perhaps different types, of functional constraint.
- University of Chicago United States
Models, Molecular, Base Sequence, Protein Conformation, DNA Restriction Enzymes, Biological Evolution, Mice, Genes, Species Specificity, Animals, Humans, Amino Acid Sequence, Cloning, Molecular, Erythropoietin
Models, Molecular, Base Sequence, Protein Conformation, DNA Restriction Enzymes, Biological Evolution, Mice, Genes, Species Specificity, Animals, Humans, Amino Acid Sequence, Cloning, Molecular, Erythropoietin
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